The story revolves around sub-zero heroes: a woolly mammoth, a saber-toothed tiger, a sloth and a prehistoric combination of a squirrel and rat, known as Scrat.
Manny, Sid and Diego discover that the ice age is coming to an end, and join everybody for a journey to higher ground. On the trip, they discover that Manny is not in fact the last of the woolly mammoths.
When Sid's attempt to adopt three dinosaur eggs gets him abducted by their real mother to an underground lost world, his friends attempt to rescue him.
Manny, Diego, and Sid embark upon another adventure after their continent is set adrift. Using an iceberg as a ship, they encounter sea creatures and battle pirates as they explore a new world.
When Scrat's acorn sends an asteroid to Earth, the Herd must find a way to stop the asteroid from hitting Earth with the help of a returning friend.