A mother takes her two young children to go visit grandma out in the woods. On the way back, the mother gets into a car accident, and the two children are forced to make it back to grandma's on their own, encountering hobos, wolves, and raging rivers along the way.
The Incredible Adventure of Jojo (and His Annoying Little Sister Avila)
How's a boy suppose to be a man with his sister always on his back?